H2N2V1, Main, Exploration, bibRecord, 002B27

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

Identifieur interne : 002B27 ( Main/Exploration ); précédent : 002B26; suivant : 002B28

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

Auteurs : Peter F. Wright [États-Unis] ; Kon Taik Khaw [États-Unis] ; Michael N. Oxman [États-Unis] ; Shwachman Harry [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1976.

RBID : ISTEX:EF87B5B5A17FF4F98612144AC67755E0B07EB3ED

Abstract

Amantadine·Hel, an antiviral drug clinically effective against most strains of influenza A virus, was evaluated in a double-blind trial in 153 children with cystic fibrosis during the initial appearance of influenza A/ England/ 42 virus in the New England area. Infection with this variant strain of influenza virus did not reach epidemic proportions during the study, so that the effectiveness of amantadine in this study population could not be fully assessed. However, the potential symptomatic and biochemical toxicity of amantadine was carefully monitored in a pediatric population. Serologic screening by complement fixation tests indicated that respiratory viruses may be important pathogens in exacerbations of respiratory disease in patients with cystic fibrosis.

Url:

https://api.istex.fr/ark:/67375/HXZ-1P46HZCW-3/fulltext.pdf

DOI: 10.1093/infdis/134.2.144

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001264
to stream Istex, to step Curation: 001264
to stream Istex, to step Checkpoint: 001694
to stream Main, to step Merge: 002C97
to stream Main, to step Curation: 002B27

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis</title>
<author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name>
</author>
<author><name sortKey="Khaw, Kon Taik" sort="Khaw, Kon Taik" uniqKey="Khaw K" first="Kon Taik" last="Khaw">Kon Taik Khaw</name>
</author>
<author><name sortKey="Oxman, Michael N" sort="Oxman, Michael N" uniqKey="Oxman M" first="Michael N." last="Oxman">Michael N. Oxman</name>
</author>
<author><name sortKey="Harry, Shwachman" sort="Harry, Shwachman" uniqKey="Harry S" first="Shwachman" last="Harry">Shwachman Harry</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:EF87B5B5A17FF4F98612144AC67755E0B07EB3ED</idno>
<date when="1976" year="1976">1976</date>
<idno type="doi">10.1093/infdis/134.2.144</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-1P46HZCW-3/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001264</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001264</idno>
<idno type="wicri:Area/Istex/Curation">001264</idno>
<idno type="wicri:Area/Istex/Checkpoint">001694</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001694</idno>
<idno type="wicri:doubleKey">0022-1899:1976:Wright P:evaluation:of:the</idno>
<idno type="wicri:Area/Main/Merge">002C97</idno>
<idno type="wicri:Area/Main/Curation">002B27</idno>
<idno type="wicri:Area/Main/Exploration">002B27</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis</title>
<author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>From the Department of Medicine and the Division of Infectious Diseases, Children's Hospital Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Please address requests for reprints to Dr. Peter F. Wright, Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khaw, Kon Taik" sort="Khaw, Kon Taik" uniqKey="Khaw K" first="Kon Taik" last="Khaw">Kon Taik Khaw</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>From the Department of Medicine and the Division of Infectious Diseases, Children's Hospital Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Oxman, Michael N" sort="Oxman, Michael N" uniqKey="Oxman M" first="Michael N." last="Oxman">Michael N. Oxman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>From the Department of Medicine and the Division of Infectious Diseases, Children's Hospital Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Harry, Shwachman" sort="Harry, Shwachman" uniqKey="Harry S" first="Shwachman" last="Harry">Shwachman Harry</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>From the Department of Medicine and the Division of Infectious Diseases, Children's Hospital Medical Center, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Infectious Diseases</title>
<title level="j" type="abbrev">J Infect Dis.</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1976-08">1976</date>
<biblScope unit="vol">134</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="144">144</biblScope>
<biblScope unit="page" to="149">149</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Amantadine·Hel, an antiviral drug clinically effective against most strains of influenza A virus, was evaluated in a double-blind trial in 153 children with cystic fibrosis during the initial appearance of influenza A/ England/ 42 virus in the New England area. Infection with this variant strain of influenza virus did not reach epidemic proportions during the study, so that the effectiveness of amantadine in this study population could not be fully assessed. However, the potential symptomatic and biochemical toxicity of amantadine was carefully monitored in a pediatric population. Serologic screening by complement fixation tests indicated that respiratory viruses may be important pathogens in exacerbations of respiratory disease in patients with cystic fibrosis.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Tennessee</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name>
</region>
<name sortKey="Harry, Shwachman" sort="Harry, Shwachman" uniqKey="Harry S" first="Shwachman" last="Harry">Shwachman Harry</name>
<name sortKey="Khaw, Kon Taik" sort="Khaw, Kon Taik" uniqKey="Khaw K" first="Kon Taik" last="Khaw">Kon Taik Khaw</name>
<name sortKey="Oxman, Michael N" sort="Oxman, Michael N" uniqKey="Oxman M" first="Michael N." last="Oxman">Michael N. Oxman</name>
<name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B27 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B27 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:EF87B5B5A17FF4F98612144AC67755E0B07EB3ED
   |texte=   Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri